Biological source: synthetic

Test: ≥90% (HPLC)

Form: liquid

Solubility

DMSO: soluble 40 mg / mL
H2O: insoluble

Compatibility: for use with ABI 7500

Sent in: dry ice

Storage temperature: −20 ° C

SMILES chain: CS (= O) CCCCN = C = S

InChI: 1S / C6H11NOS2 / c1-10 (8) 5-3-2-4-7-6-9 / h2-5H2,1H3

InChI key: SUVMJBTUFCVSAD-UHFFFAOYSA-N

Request

LNCaP prostate cancer cells were treated with DL-sulforaphane to study the effect on the androgen receptor. The effects on malathion toxicity in rats were studied by treating them with DL-sulforaphane.

Biochemical / Physiological Actions

Selective inducer of phase II detoxification enzymes with anti-cancer properties. An organic sulfur compound found in cruciferous vegetables, including broccoli. Sulforaphane is an anticancer, antimicrobial, and antidiabetic compound found in cruciferous vegetables.

It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β, and TNF-α.

Other notes

Tandem mass spectrometry data independently generated by the Scripps Center for Metabolomics is available to view or download in PDF. S4441.pdf The metabolites tested are presented in the METLIN Metabolite Database of the Scripps Center for Metabolomics.

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